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Torin 1
Cat. No.:
OB0225LY-0464
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Product Overview
Description:
Torin 1 is a selective mTOR inhibitor that effectively inhibits the activity of mTORC1 and mTORC2.
Synonym:
1222998-36-8; Torin-1; TorIN1; 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[H][1,6]naphthyridin-2(1H)-one; 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[H]-1,6-naphthyridin-2(1H)-one; 1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[H]-1,6-naphthyridin-2(1H)-one
CAS No.:
1222998-36-8
Compound CID:
49836027
Formula:
C35H28F3N5O2
Formula Weight:
607.62
Specification
Relative Density:
1.362 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Torin 1 can be used to explore mechanisms of cell growth and metabolic regulation.
Library Information
Targets:
PIKKs; PI3K class I subunits
Receptors:
DNA-PK; mTORC1; mTORC2; p110γ
Pathways:
DNA damage/DNA repair; Autophagy; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-6
Plate Location:
h11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
2 mM DMSO
DMSO Max Solubility:
1 mg/mL
Solubility:
10% DMSO+90% Saline: 0.15 mg/mL (0.25 mM)
ALogP:
5.914
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
5
