Rabbit Obesity Model

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Overview of Rabbit Obesity Model

Protheragen is committed to promoting the development of global health science research, especially in the treatment of obesity and its related diseases. We provide comprehensive Preclinical Studies of Anti-Obesity Therapeutics. As an important part of this service, we focus on building and optimizing various Obesity Models especially In Vivo Obesity Models for Obesity Research to simulate the complex physiological and pathological processes of human obesity. Here, we introduce the construction and evaluation service of the rabbit obesity model in detail. This model is ideal for studying obesity and its complications due to its unique physiological characteristics and sensitivity to high-fat diets.

We leverage our rabbit obesity model as a pivotal tool for evaluating and fostering Anti-Obesity Therapy Development. This model, known for its sensitivity to dietary and metabolic manipulations, offers a unique window into the dynamics of Anti-Obesity Small Molecule Drug Development and Anti-Obesity Nanotherapy Development. By replicating the complex interplay of factors leading to obesity in humans, it enables us to rigorously test the efficacy and safety of our therapeutic candidates.

Unlock the Future of Obesity Research with Our Cutting-edge Rabbit Obesity Model Development Service

Rabbit Selection

We utilize specific rabbit breeds known for their predictable responses to dietary modifications, such as New Zealand white rabbits. Rabbits aged between 8-12 weeks are selected to ensure optimal growth and developmental stages are aligned with the study objectives.
Dietary Intervention

High-Fat Diet (HFD): Rabbits are fed a carefully formulated high-fat diet to induce obesity. This diet mimics common human dietary patterns that contribute to obesity.

Control diet: A standard rabbit diet is used for control groups to provide comparative baseline data.
Monitoring and Evaluation

Weight and body fat monitoring: Regular measurements of body weight and fat accumulation are conducted.

Cardiovascular assessments: Mean arterial pressure (MAP) and heart rate (HR) are monitored to study cardiovascular function changes in response to obesity.

Blood sample analysis: Blood samples are collected regularly to test blood glucose, blood lipids (such as total cholesterol, and triglycerides), insulin, leptin, and other metabolic-related indicators.

Tissue sample analysis: When necessary, a biopsy of target organs such as adipose tissue and liver is performed to evaluate tissue morphology and molecular biological changes.

Behavior and activity monitoring: We use an automated activity monitoring system to record the rabbit's daily activity, feeding behavior, etc., to evaluate the impact of obesity on animal behavior.

Workflow

Schematic diagram of rabbit obesity model construction. (Protheragen)

Applications of Rabbit Obesity Model

Nutritional research: This model can be used to study the effects of different dietary ingredients on rabbit weight gain, fat distribution, and metabolic processes.
Genetic research: This model helps scientists explore the variation and expression patterns of obesity-related genes and reveal the genetic mechanism of obesity.
Metabolic disease research: This model helps understand how obesity leads to the occurrence of metabolic diseases such as insulin resistance and high cholesterol.

Advantages

Professional customization: We provide customized rabbit obesity models according to client needs to ensure that the model is highly matched with specific research goals.
Comprehensive service: We provide a one-stop service to reduce client research costs and improve research efficiency.
Rich experience: We have many years of experience in animal model research and development.

Publication

Technology: Establishment of rabbit obese model using diet-induced approaches

Published: 2019

Journal: Animals

IF: 3.0

Results: The authors conducted a study to establish a rabbit obese model using diet-induced approaches to simulate metabolic syndrome (MetS). The methodology involved acclimating New Zealand white rabbits for 2–3 weeks, followed by segregating them into control and experimental groups. The experimental group was provided with diets enriched in different components, ranging from high-fat, cholesterol, sucrose, or fructose, over periods varying from 8 to 48 weeks. Monitoring included evaluating obesity, hyperglycemia, hypertension, dyslipidemia, and free fatty acids. High-fat diets incorporated oils like coconut oil and lard, while cholesterol diets reached up to 2% cholesterol. Sucrose and fructose-rich diets combined with fats induced components of MetS such as insulin resistance and central obesity. The assessment involved biochemical assays for lipid profiles, glucose levels, blood pressure measurements, and physiological examinations to confirm the successful model establishment.

Fig.1 Comparation of metabolic syndrome animal models. Fig.1 Comparation of MetS animal models. (Lozano, et al., 2019)

Our Services

Obesity Biomarker Identification and Analysis Service

Linked closely with our rabbit obesity model is our obesity biomarker identification and analysis service. This service is of paramount importance as it enables the precise identification and quantification of biomarkers associated with obesity. By analyzing key biomarkers such as Triglycerides and Visfatin, we provide valuable data that can be used to assess obesity-related risk, monitor disease progression, and evaluate the efficacy of therapeutic interventions.

Frequently Asked Questions

How is your rabbit obesity model constructed?

Our rabbit obesity model is constructed through a carefully designed feeding program and high-precision nutritional regulation. We use scientifically formulated feed to control the balance between energy intake and expenditure and combine gene editing technology to accelerate the model-building process and ensure its stability and reliability. The entire construction process strictly follows animal ethics and experimental specifications.

What types of research is this model suitable for?

The rabbit obesity model is widely used in drug development, nutrition, genetics, metabolic diseases, exercise physiology, teaching demonstrations, and policy making. It is particularly suitable for evaluating the effectiveness of anti-obesity drugs, studying the pathophysiological mechanisms of obesity-related diseases, and exploring the effects of nutritional interventions on obesity.

Protheragen focuses on providing high-quality and customized rabbit obesity model development services. We use scientific feeding and management methods to create a stable and reliable rabbit obesity model for our clients, helping to achieve scientific breakthroughs in drug development, nutrition, metabolic disease research, and other fields. Please feel free to contact us for more details if you are interested in our rabbit obesity model development services!

Reference

Lozano, W.M.; et al. Diet-induced rabbit models for the study of metabolic syndrome. Animals. 2019, 9(7): 463.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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