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Obesity Gene Panel Test Service

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Overview

Workflow of obesity gene panel test. (Protheragen)

The obesity gene panel test is rooted in extensive research that explores the genetic factors contributing to obesity. Over the past few decades, advances in genomics have identified numerous genes associated with weight regulation, fat storage, and metabolism. Studies have shown that genetic variations can significantly impact an individual's susceptibility to obesity, influencing how their body responds to different diets and exercise regimens. This test leverages the latest scientific discoveries to provide a comprehensive analysis of these genetic markers, offering insights that go beyond traditional risk factors. By integrating these findings into personalized health strategies, the obesity gene panel test aims to help individuals understand their genetic predispositions and make more informed lifestyle choices to better manage and prevent obesity.

Personalize Your Path to Wellness with Our Obesity Gene Panel Test

Protheragen is deeply committed to the research related to obesity, with an emphasis on creating innovative treatments for addressing this issue. Our research encompasses key areas such as Identifying New Targets for Anti-Obesity Treatments, including Hormones and Peptides, Receptors, Enzymes and Proteins, Metabolic Regulators, and Signaling Molecules. Additionally, we are committed to advancing the development of Anti-Obesity Therapies to offer patients more effective treatment options such as  Small Molecule Drugs, Gene Therapy, Cell Therapy, Antibody Therapy, Tissue Engineering Therapy, and Nanotherapy. We additionally perform Preclinical Studies on Anti-Obesity Therapeutics to confirm their safety and efficacy. Through our efforts in these areas, we aim to contribute towards addressing the issue of obesity and enhancing people's health and well-being. The preclinical studies on anti-obesity therapeutics we conduct include but are not limited to the following.

Based on our extensive research experience in the field of obesity, we offer clients specialized Obesity Causation Analysis Services from various perspectives, including but not limited to Genetically Induced Obesity, Disease-Induced Obesity, and Medication-Induced Obesity. Our Monogenic Obesity Gene Test Service and obesity gene panel test service have been positively received by our clientele. The obesity gene panel test services we provide include but are not limited to the following.

Non-Syndromic Monogenic Obesity Panel Test Service

We provide in-depth genetic analysis focusing on non-syndromic types of monogenic obesity. This helps you uncover the genetic roots of weight management by testing for specific single gene variants associated with obesity.

Comprehensive Monogenic Obesity Panel Test Service

Tests cover a wide range of single gene variants to help you accurately identify the genetic risks associated with obesity so that you can develop a personalized health plan. With this service, you can gain an in-depth understanding of weight management.

Diabetes-Obesity NGS Panel Test Service

We offer advanced technology that provides insight into the genetic factors associated with diabetes and obesity. Combining comprehensive genetic testing for diabetes and obesity to help you reveal the complex relationship between the two.

Bardet-Biedl Syndrome (BBS) Panel Test Service

Our BBS panel test service specializes in comprehensive testing for genetic variants associated with BBS. Utilizing advanced gene sequencing technology to accurately identify multiple genetic variants, helps you understand your genetic risk.

Workflow

  • Sequencing Sample Preparation 

    The initial processing of the samples and the extraction of DNA from the samples requires the use of specific chemical reagents and equipment to ensure that high-quality DNA samples are obtained for subsequent genetic analysis. We then amplify the target gene region using polymerase chain reaction (PCR) technology, which generates a sufficient amount of DNA for detailed analysis and sequencing. The amplified samples are then assayed for concentration to ensure that they meet the sequencing concentration.

  • Gene Sequencing

    We fully sequence and analyze amplified regions of DNA through next-generation sequencing (NGS) or other gene sequencing technologies. Sequencing technology reads the sequence information of the DNA and identifies genetic variants associated with obesity.

  • Data Analysis and Interpretation

    We use computational tools and databases to bioinformatically analyze the data generated by sequencing to ensure accurate interpretation of the data. Genetic markers and variants associated with obesity are identified by comparing and analyzing gene sequences. Based on the results of the analysis, a test report is generated. The report details the genetic variants detected, the genetic risk assessment, and the associated scientific interpretation. The results of the analysis are collated into an easy-to-understand format and personalized health advice is provided.

Fig.1 Genetic testing results reveal mutations that are not within the normal range.

Applications

  • By identifying the genetic susceptibility associated with obesity, the test helps develop diet and exercise recommendations that match an individual's genetic profile. 
  • This test provides information on the risk assessment for obesity-related diseases such as type 2 diabetes, cardiovascular disease, and metabolic syndrome. Early knowledge of these risks can lead to preventive measures and lifestyle modifications that can reduce the incidence of related diseases. 
  • Obesity gene panel tests can reveal genetic barriers that may affect weight loss progress. This information can help develop targeted strategies to improve the chances of successful weight loss.

Advantages

  • The test uses advanced gene sequencing technology to accurately identify genetic markers associated with obesity.
  • We comprehensively assess the genetic risk by analyzing multiple genes and genetic variants associated with obesity.
  • Based on the latest scientific findings and technological advances, our obesity gene panel test incorporates the latest genetic discoveries to provide users with the most up-to-date and effective genetic information.

Publication Data

Technologies: Sanger sequencing, NGS, Whole-exome sequencing (WES)

Journal: Obesity Reviews

Published: 2024

IF: 10.867

Results: This article examines various sequencing techniques, the functional analysis of mutations, and the frequency and penetrance of rare coding mutations in genes associated with single-gene obesity. It offers a thorough review and synthesis of rare coding mutations within the leptin-melanocortin pathway by systematically evaluating these specific genes. Key topics covered include the use of sequencing methods, characterization of mutation functions, as well as their prevalence and penetrance. The study primarily focuses on mutations found in several single-gene obesity-related genes.

Frequently Asked Questions

What is the obesity gene panel test?

The obesity gene panel test is a genetic testing service that helps you understand your genetic susceptibility by analyzing genetic markers associated with obesity. This test can provide personalized information about weight management and obesity risk.

Does the test detect all known obesity-related genes?

The range of genes tested depends on the gene panel used. It usually contains key genes known to be associated with obesity, but may not cover all known obesity-related genes. We will communicate with you in advance to confirm the specific gene list.

Protheragen offers a comprehensive and precise obesity gene panel test service, which aims to uncover the genetic factors linked to obesity. Through advanced gene sequencing technology, we examine genetic variations closely related to weight control, providing valuable insights into your unique genetic makeup. If you need our services, please feel free to contact us!

Reference

  1. Dosda, S.; et al. Sequencing methods, functional characterization, prevalence, and penetrance of rare coding mutations in panels of monogenic obesity genes from the leptin-melanocortin pathway: A systematic review. Obesity Reviews. 2024: e13754.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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